Our Accomplishments

• Grown from 150 to 500+ members in the last 5 years, representing 75 institutions and 20+ countries
• $24.4 million in grant funding received by CARG members utilizing this new infrastructure
• 95+ publications attributed to the grant (high impact journals include Lancet, JAMA Onc, JCO, Cancer)
• 170+ inquiries received and addressed utilizing the infrastructure

• Since 2017, CARG has grown from 150 to over 500 members representing over 75 institutions and 20 countries.
• Go-to website for cancer and aging scholars (www.mycarg.org)
• Bi-weekly CARG virtual calls averaging 60-80 participants
• Awarded 7 out of 9
• 170+ inquiries received and addressed to date from investigators utilizing the CORES, SCOREBoards, CARG Biweekly Meetings, and/or Leadership team.
• CARG Statement on Diversity, Equity, Inclusion, and Justice developed and disseminated by the Communications Core, in collaborations with CARG, Advocacy Committee, Junior Investigator Board, CARG Leadership and AGS.
• CARG Research Report - quarterly newsletter disseminated via email and on the CARG website to highlight the latest in cancer and aging research and CARG members accomplishments.
• Collaboration with the:
  • NCI (CARG member leadership and participation in NCI let and cancer and aging workshops)
  • FDA (guidance on inclusion of older adults on cancer clinical trials)
  • AGS (CARG DEI Statement)

• Measures Core
  The goal of the Measures Core is to accelerate the pace of discovery and collaboration between investigators by providing resources to inform the use of appropriate clinical and biological measures of aging within the context of cancer and aging research.
• Supportive Care Core
  The goal of the Supportive Care Core is to create effective interventions to improve health outcomes for older adults. Areas with great promise are interventions from the behavioral, psychological, and supportive care arenas. Designing such intervention studies for vulnerable older adults requires care and expertise in aging applied early in research study design.
• Analytics Core
  The goal of the Analytics Core is to provide feedback on how data could be used to support the design and implementation of new research. These include outcome choices most relevant to older adults, inclusion of those most likely to have the disease, and sample size/power issues for inclusion of sufficient numbers of older adults.
• Clinical Implementation Core
  The goal of the Clinical Implementation Core is to support clinical healthcare professionals interested in integrating aging principles into cancer clinical care in efforts to develop Geriatric Oncology practices, and thus promote the growth of a global coordinated geriatric oncology clinical network that would foster collaborations around implementation of clinical practices, quality improvement, and research.
• Health Services Core
  The Core mission is to support clinical investigators to design and conduct high-quality health services research focused on older adults with cancer and caregivers including patterns of care, comparative effectiveness, and care delivery.
• Communication Core
  The goal of the Communication Core is to promote awareness about CARG and its offerings, build engagement and capacity among researchers, recruit new investigators, engage individual institutions and national organizations critical to CARG’s sustainability, and reframe how broader oncology world views aging and needs associated with care of older adults.

Core Inquiry: If you have a research inquiry for any Core, please complete the Research Inquiry Form here:

• Detailed table of measure available based on geriatric assessment domains.
• List and resources of public datasets for geriatric oncology research
• CARG DEI Statement
• CARG Research Report

• 51 grants submitted; 27 grants funded to date.
• 26 Career Development Awards submitted.
• 16 funded ($11.7 million)
  • 6 R03 GEMSSTARs.
  • 7 k awards (3K76 Beesons, 2 K08s, 1 K01, 1 K99/R00)
  • Other Grants: ASCO CDA, ACS CDA, VA IK2 grants
• 2 NIA grants pending NOA’s (fundable scores for K76 and R03).
• 25 Research Grants Submitted
• 11 funded ($12.7 million)
  • 2 R01s, 1 R21, 1 U01, and foundation, pharma, and institutional grants
  • $4.25 million to support a CARG National Consortia of Geriatric Oncology Trials (5 GA-guided RCTs) funded through the Rising Tide Foundation ($2.25 million), institutional support (6 institutions participating) and generous donors.

95 total publications (48 publications co-authored by at least on MPI)
Highlights

• The American Society and Clinical Oncology (ASCO) Guidelines in geriatric oncology (Mohile et al. JCO 2018)
• Systematic review highlighting barriers and interventions for older adult participation in cancer clinical trials (Sedrak et al. CA Cancer J Clin 2021)
• CARG Leadership led a Journal of Clinical Oncology Special Issue. "Caring for Older Adults with Cancer" (16 articles co-authored by CARG members)
• Two large, practice-changing randomized controlled trials showing the benefits of a validated geriatric assessment (GA)-based intervention to decrease chemotherapy toxicity (Mohile et al. Lance 2021; Li et al. JAMA Onc 2021)
• Development and validation of the CARG Breast (CARG-BC) Toxicity Tool (Magnuson et al. JCO 2021)
• Secondary analyses of large geriatric assessment CARG datasets (e.g. Presley et al. Front Oncol. 2022; Klepin et al. JCO Oncol Pract 2021; Dotan et al. Cancer 2020)
• Validation of the CARG Toxicity Tool in Other Countries/Languages (Suto et al. Cancers (Basel) 2022); Bergerot et al. JGO 2020).

Other aspects of the research infrastructure

• SCOREboard: 23 inquiries received and addressed. Developed and implemented patient advocate recruitment process for board. Currently there are 10 members
• Junior Investigator Board: Hosted Career Development Workshop for early career investigators (45 participants, positive reviews, rating 4.8/5.0)
• CARG Advocacy Committee: Developed and implemented 2 surveys on the impact of COVID-19 on older adults with cancer (BrintzenhofeSzoc et al. JGO 2021; Krok-Schoen et al. JGO 2021).
• CARG Buddy Task Force: 54 mentee-mentor matches representing 43 institutions and 4 countries